All three vaccines are given through a series of three injections into muscle tissue over a 6-month period.

In October 2016, the FDA approved a 2-dose schedule for boys and girls initiating vaccination with Gardasil 9 at ages 9 to 14 years (the second dose is to be administered 6–12 months after the first).

Sexually transmitted HPV types fall into two categories: HPV infections are the most common sexually transmitted infections in the United States.

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HPV is easily passed between partners through sexual contact.

HPV infections are more likely in those who have many sex partners or have sex with someone who has had many partners.

They can be spread by vaginal, anal, and oral sex (1).

Other HPV types are responsible for non-genital warts, which are not sexually transmitted.

The FDA has approved Gardasil and Gardasil 9 for use in females ages 9 through 26 for the prevention of HPV-caused cervical, vulvar, vaginal, and anal cancers; precancerous cervical, vulvar, vaginal, and anal lesions; and genital warts.

Gardasil and Gardasil 9 are also approved for use in males for the prevention of HPV-caused anal cancer, precancerous anal lesions, and genital warts.Correct and consistent condom use is associated with reduced HPV transmission between sexual partners, but less frequent condom use is not (8).However, because areas not covered by a condom can be infected by the virus (7), condoms are unlikely to provide complete protection against the infection.In addition to providing protection against the HPV types included in these vaccines, the vaccines have been found to provide partial protection against a few additional HPV types that can cause cancer, a phenomenon called cross-protection.The vaccines do not prevent other sexually transmitted diseases, nor do they treat existing HPV infections or HPV-caused disease.Those initiating the HPV vaccination series at older ages (including teens who begin getting vaccinated after they turn 15 years old) or who are immunocompromised should still be vaccinated according to the 3-dose schedule.